The loss is the first for the Spartans on the Rebels home court in the last three years.
Cydni Lewis had a career-best 10 rebounds and added nine points for the Spartans.
The Spartans have defeated Fresno State in three of its last four meeting in The Event Center.
SJSU defeated UNLV in Las Vegas two weeks ago and with a win can sweep its second season-series of the year.
Spartans looking to take back-to-back MW road games with a win in San Diego.